Septic shock—an update

Septic shock in ICU: update in hemodynamic monitoring

One of the cornerstones of treatment of the patient in shock is the use of intravenous fl uids.4 However, its use and dosage is still carried out empirically. Fundamentally, the only reason for providing fl uids to a critically ill patient is to increase the systolic volume (SV) and, in this manner, the cardiac output (CO).5 However, taking into consideration that only 50% of critical patients ...

Update in the Treatment of Severe Sepsis and Septic Shock

Neonatal sepsis and septic shock: concepts update and review.

The nonspecific presentation of neonatal sepsis and systemic inflammatory response syndrome preceding septic shock delay the early diagnosis of septic shock and increase its mortality rate. Early diagnosis involves suspecting septic shock in every newborn with tachycardia, respiratory distress, difficult feeding, altered tonus and skin coloration, tachypnea and reduced perfusion, specially in c...

Neonatal Sepsis: An Update

Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and il...

The Role of ACTH and Corticosteroids for Sepsis and Septic Shock: An Update

Sepsis is a common disorder associated with high morbidity and mortality. It is now defined as an abnormal host response to infection, resulting in life-threatening dysfunction of organs. There is evidence from in vitro and in vivo experiments in various animal models and in patients that endotoxin or sepsis may directly and indirectly alter the hypothalamic-pituitary-adrenal response to severe...